The Role of 2-[18F]-FDG PET/CT in Detecting Richter Transformation in Chronic Lymphocytic Leukemia: A Systematic Review

Richter transformation (RT) is a condition wherein B cell chronic lymphocytic leukemia (CLL) transforms into more aggressive lymphoma variant. The incidence and the significance of RT detected by 2-[18F]-FDG PET/CT clinical challenge it not widely investigated in literature. aim this systematic review was to analyze published data about potential role detecting RT. A comprehensive computer literature search PubMed/MEDLINE, Embase Cochrane library databases conducted up December 2020. Thirteen studies (1336 patients with CLL) were selected. maximum standardized uptake value (SUVmax) most common metabolic parameter used detect An SUVmax 5 had an average overall sensitivity 87% (range: 71–96%), specificity 49% 4–80%), positive predictive 41% 16–53%) negative 84% 33–97%). Other variables only marginally investigated, promising results. imaging may play important detection CLL, based on high activity nodal lesions that transformed lymphomas. has for evaluating